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Change in the base sequence of a genome that has the effect of reducing the fitness of the so-affected organism.
Detrimental mutations simply are mutations that negatively impact an organism's ability to survive and/or reproduce. See also allele.
See, similarly, detrimental allele as well as deleterious allele, and even lethal allele. Contrast with beneficial mutation and beneficial allele as well as neutral mutation and neutral allele, as well as allele (neutral).
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