Type IV Hypersensitivity

∞ generated and posted on 2016.03.20 ∞

Delayed, cytotoxic T lymphocyte-mediated damage to otherwise healthy cells and tissues following autoimmune reactions or exposure to exogenous antigens.

Type IV or delayed hypersensitivities form the basis of allergies to poison ivy, nickel in jewelry, and latex, such as can be found making up condoms and surgical gloves.

Positive reactions in the skin test for tuberculosis (tuberculin skin test) are also due to delayed hypersensitivity reactions.

Autoimmune diseases that are due to type IV hypersensitivities include Diabetes mellitus type 1 and Rheumatoid arthritis.