Acute Phase Proteins

∞ generated and posted on 2016.03.18 ∞

Body signaling molecules whose blood plasma concentrations rise and fall in the course of inflammatory responses.

Stimulation of toll-like receptors results in release of cytokines such as by macrophages. These cytokines, once they reach the liver, stimulate the production of acute-phase proteins.

Additional acute-phase proteins reside in the blood and are activated in response to inflammation. The active and release acute-phase proteins in turn contribute to the development and maintenance of the inflammatory response.

Acute-phase proteins can be differentiated into those whose increase corresponds to an increase in inflammation and those whose increase corresponds to a decrease in inflammation (and therefore which decrease in concentration during inflammation).