∞ generated and posted on 2022.02.06 ∞
Idea that bacterial strains can differ in their phage resistance for reasons that have little or nothing to do with their having any previous exposure to phage therapy.
| Community Resistance is simply a way of describing how bacterial strains can vary in their phage resistance for a multitude of reasons, not just having to do with phage exposure and/or with phage therapy, with 'community' defined in human terms, i.e., what 'bugs' are circulating in our, e.g., cities. |
It is to address the issue of community resistance that a prêt-à-porter phage cocktail needs to possess a relatively broad breadth of activity.
One can also consider community resistance to represent something of an ecological phenomenon in terms of phenotypic variation in phage susceptibility within a given environment, which could very well be evolutionarily static (unchanging over time) but still an issue that phage therapy needs to deal with.
Community resistance can also be relevant to presumptive treatment using phages, a.k.a., empirical treatment, though is important as well even if targeted bacteria are tested for phage cocktail sensitivity prior to the start of treatments as it will help to define how broadly effective a phage cocktail will be within a human community.
See by contrast treatment resistance.
Next | Previous phage therapy-related terms: Cross resistance | Cocktail.
See Google Scholar for References.