Type I Hypersensitivity

∞ generated and posted on 2016.03.20 ∞

Allergic reaction associated with IgE, mast cells, basophils, and release of histamine.

Type I hypersensitivities are the most familiar of hypersensitivities. They result is anaphylaxis. Medically, one means of addressing symptoms associated with type I hypersensitivities is by taking antihistamine drugs. See also desensitization.

IgE is produced by B cells – that is, by plasma cells – but binds to basophils and mast cells, leaving their antigen binding sites free. The subsequent binding of this granulocyte-bound IgE antibody to antigen (that is, allergen), particularly by adjacent IgE found on the same leukocyte, results in degranulation and effector release, such as of histamine.