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Binding of a methionine-carrying aminoacyl tRNA to a combination of the first AUG of a reading frame on an mRNA along with the coming together of the large and small ribosomal subunits.
Involved in translation initiation, crucially, is also what is known as the ribosome binding site, which is a sequence of bases found in the mRNA to which, not surprisingly, the ribosome binds. This starts the initiation of translation, which then progresses through the steps outlined above.
See also translation elongation and translation termination. Compare with transcription initiation. See too simply translation.
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